Fasenra contains the active drug benralizumab, while Nucala contains the active drug mepolizumab. It is also used in patients whose asthma has an eosinophilic phenotype. The fevers werent serious and didnt cause any problems with peoples asthma treatment. Fasenra may be injected in different parts of your body such as your upper arms, thighs, or belly. A program called Fasenra 360 may also help lower the cost of the drug. This makes it easier for you to breathe. Fasenra may be used in children ages 12 years and older. Also remember to tell your doctor about any other side effects that you may be experiencing, such as headache or back pain. The exact way Fasenra works in asthma has not been definitively established. So you shouldnt use it to treat asthma flare-ups or a severe kind of asthma called status asthmaticus. With eosinophilic asthma, you also experience high levels of eosinophils (a type of white blood cell). If you are a caregiver administering Fasenra to another person, it may also be administered into the upper arm. Uncontrolled asthma is when a person has frequent and disruptive asthma symptoms, such as wheezing, chest tightness, or asthma attacks. So you shouldnt them to treat asthma flare-ups or a severe kind of asthma called status asthmaticus. The expiration date helps guarantee that the medication is effective during this time. Its not known if Fasenra is safe to take during pregnancy. A biosimilar is a drug thats similar to a brand-name medication. Along with its needed effects, benralizumab (the active ingredient contained in Fasenra) may cause some unwanted effects. If there is a clear pattern of weight gain, talk with your doctor. Your doctor will tell you more about the other asthma medications youll take together with Fasenra. Fasenra attaches to eosinophils by binding to this receptor. inflammation of the gums pain with menstruation arthritis joint pain muscle pain nerve pain a sleep disorder chills cough abdominal bloating pelvic pain nervousness a sensation of. In addition to the use listed above, Fasenra may be used off-label for other conditions. Such studies help doctors learn more about the safety of certain drugs during pregnancy. This type of drug is a large protein that affects the way certain parts of your body work. Tell them about all prescription, over-the-counter, and other drugs you take. Or you may be able to give yourself injections at home. In studies of Fasenra, people took the drug along with a high dose inhaled corticosteroid (ICS) and a long-acting beta agonist (LABA). In certain people, Xolair is also approved to treat: Youll use Xolair with your other asthma medications rather than by itself. Asthma is called severe when you keep having symptoms despite using multiple asthma treatments. Since oxygen is carried in air, this condition reduces how much oxygen reaches the cells inside your body. The Food and Drug Administration (FDA) has approved Fasenra and Nucala to treat severe eosinophilic asthma in adults as well as children. Sharing this information can help you avoid potential interactions. However, these should not be discontinued abruptly. The current stance of the Food and Drug Administration (FDA) is to avoid using expired medications. It is unknown what effect Fasenra has on an unborn baby. redness of the skin, swelling of the eyelids, face, lips, hands, or feet, tightness in the chest, trouble swallowing, cough, dizziness, and. It also enhances the apoptosis of basophils. Fasenra is approved to treat severe eosinophilic asthma in children ages 12 years and older. Fasenra works by attaching to eosinophils. This can help avoid any potential drug interactions. Check the liquid in the Fasenra Pen. People who took either Fasenra or Nucala had fewer flare-ups than people who took a placebo (treatment with no active drug). Learn about dosage and more. Bring someone with you to your appointment if doing so will help you feel more comfortable. Fasenra may increase your risk of herpes infection. There have been no formal interaction studies conducted with Fasenra, according to the product information, and no interactions are documented. IGG ANTIBODIES AND . Fasenra undergoes degradation by proteolytic enzymes throughout the body. Theyll recommend whether the drug is a good option for you. It is also used in patients whose asthma has an eosinophilic phenotype. Youll often take steroids every day for long-term treatment, or you may take them just during asthma flare-ups. What should I know about Fasenra vs. Nucala? Fasenra also shouldnt be used to treat other eosinophilic conditions. During the first 3 months of treatment, youll have one injection (30 mg/mL) once every 4 weeks. Stopping treatment may reduce the effect of Fasenra and lead to asthma flare-ups. In clinical studies, only 3% of people who took Fasenra had an allergic reactions. What to Do If Your Asthma Treatment Stops Working, 14 Natural Ways to Help Treat Severe Asthma. Remove the autoinjector. Initially, your doctor will administer it, but during your appointment, they will discuss teaching you how to administer the Fasenra autoinjector pen so that you can administer it at home. (For more information, see the What is the Fasenra injection used for? section above.). But higher levels can cause swelling in your airways and lead to severe eosinophilic asthma. Call your doctor if you think youve taken too much Fasenra. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. By targeting this receptor, Fasenra promotes destruction of these cells via antibody-dependent cell-mediated cytotoxicity. All rights reserved. A single copy of these materials may be reprinted for noncommercial personal use only. You can also call 800-222-1222 to reach the American Association of Poison Control Centers, or use its online resource. Certain factors may affect how well Fasenra works to treat asthma. If you drink alcohol, talk with your doctor about how much is safe for you to consume during your Fasenra treatment. These factors include what your insurance plan covers and which pharmacy you use. A significant improvement in lung function was also observed 4 weeks after Fasenra was administered. There is no information on the safety of Fasenra during breastfeeding. Appropriate studies have not been performed on the relationship of age to the effects of benralizumab injection in children younger than 12 years of age. Do not shake. Data sources include IBM Watson Micromedex (updated 2 Apr 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. Fasenra may cause joint pain. Detailed drug Information for Fasenra. Do not warm it in any other way. Fasenra (benralizumab)." However, you shouldnt suddenly stop or change your use of corticosteroids on your own. Clearance of Fasenra is not impacted by renal or hepatic function, age, gender, or race. By binding to IL-5R, Fasenra prevents IL-5 from binding and its alpha and beta subunits from interacting. Note: You should not use Fasenra to treat an asthma attack (sudden worsening of asthma symptoms). 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). If you are at high risk, your doctor may consider vaccination against herpes. Your doctor can also recommend the safest ways to feed your child. Its a type of drug called a biologic. Fasenra (Benralizumab Prefilled Syringes), swelling of the eyelids, face, lips, hands, or feet, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue. And if your asthma symptoms ever feel life threatening, call 911 or seek emergency medical help. They can help determine the cause of your symptoms and recommend ways to manage them. But if you have severe symptoms, immediately call 911 or your local emergency number. Youll go to your doctors office or a clinic for the injections. When you get Fasenra from the pharmacy, the pharmacist will add an expiration date to the label on the bottle. Check the liquid in the Fasenra Pen. Some drugs may be better suited for you than others. This means benralizumab is the ingredient that makes Fasenra work. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Fasenra isnt currently approved to treat nasal polyps. If you have questions about steroids or Fasenra, ask your doctor or pharmacist. Fasenra can be used in adults as well as children ages 12 years and older. If your dose is different, do not change it unless your doctor tells you to do so. The Food and Drug Administration (FDA) approves prescription drugs such as Fasenra to treat certain conditions. No, Fasenra isnt used to treat chronic obstructive pulmonary disease (COPD). But alcohol can be dangerous for people with asthma. In certain people, Nucala is also approved to treat: Each syringe or pen contains one dose of Fasenra. Other drugs are available that can treat severe eosinophilic asthma. Serious side effects from Fasenra can occur, but they arent common. Biologics are made from living cells rather than from chemicals. In the first study, 35% of people who took Fasenra had asthma flare-ups, compared with 51% of people who took a placebo. In clinical studies, sore throat occurred in 5% of people taking Fasenra compared with 3% of people who took a placebo. However, if you develop a side effect that doesnt go away, talk with your doctor. To learn more about this side effect, see Allergic reaction just below. Do not use this medicine if it is cloudy or if there are particles in it. It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly and to check for unwanted effects. Eosinophils (a type of white blood cell) are found in your airways. Before you begin treatment, talk with your doctor and pharmacist about this. If you have a parasitic infection, it should be treated before you start Fasenra. Instead, reductions should be gradual and performed under the direct supervision of a physician. Like most drugs, Fasenra may cause mild or serious side effects. The improvement in exacerbation rates started to appear 4 weeks after administration with Fasenra, suggesting that it begins to have a beneficial effect shortly after patients start taking it. These effects are called interactions. If you have asthma, talk with your doctor about whether its safe for you to consume alcohol. Certain pharmacies may provide medication labels that: Your doctor or pharmacist may be able to recommend a pharmacy that offers these options if your current pharmacy doesnt. It then sends signals to other cells in your body to destroy the eosinophils. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. No, Fasenra isnt known to cause long-term side effects. If youre breastfeeding or plan to breastfeed, talk with your doctor before taking Fasenra. Headaches, fever, pharyngitis (inflammation of the back of the throat), and injection site reactions (redness, pain, itching, or swelling at the injection site), are the most common side effects reported with Fasenra. Theres no known interaction between alcohol and Fasenra. Do not shake. Symptoms can include: Swelling Stiff or enlarged joint Numbness Noisy joints, or clicking, grinding, or snapping sounds when moving the joint Painful movement Difficulty bending or straightening the joint Loss of motion A red and hot and swollen joint (This should be evaluated quickly by a doctor) When should I see a doctor? But they can also cause some different side effects. Heres a comparison of how Fasenra and Xolair are alike and different. Portions of this document last updated: Feb. 01, 2023, Original article: https://www.mayoclinic.org/drugs-supplements/benralizumab-subcutaneous-route/side-effects/drg-20406682. Off-label drug use is when a drug thats approved for one condition is used for a different one thats not approved. A review of studies supports using medications that are in the same class as Fasenra to treat nasal polyps. The recommended dose of Fasenra is 30 mg every 4 weeks for the first 3 doses, followed by once every 8 weeks thereafter. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. Fasenra is meant to be used with the other medications youre taking for asthma treatment. But with this condition, the cells mistakenly attack your bodys airways. Keep in mind that side effects of a drug can depend on: Your doctor or pharmacist can tell you more about the potential side effects of Fasenra. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. To learn more about how Fasenra and Dupixent are alike and different, ask your doctor or pharmacist. Two clinical studies looked at 2,510 people with severe eosinophilic asthma. It reaches distribution volumes of 3.1 L (central) and 2.5 L (peripheral) in people weighing 154 pounds (which is about 70 kilograms). With the prefilled autoinjector pen form, youll use the pen to give yourself injections after you receive training from a healthcare professional. You can also talk with your doctor or pharmacist to learn more about Fasenra and your other asthma medications. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. The most common side effects of Fasenra include: (Biologics are medications made from living cells rather than chemicals.). Both Fasenra and Xolair are called biologic drugs because theyre made from living cells rather than from chemicals. With this condition, high levels of eosinophils (a type of white blood cell) are found in your airways. As with most drugs, some people can have an allergic reaction after taking Fasenra. As a result, air cant move properly into and out of your lungs. To avoid missing a dose of Fasenra, try setting a reminder on your phone or calendar. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Fasenra only for the indication prescribed. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Throw away any medicine left out of the refrigerator for more than 14 days. Dupixent belongs to a different class of drugs called interleukin-4 monoclonal antibodies. There are no known pharmacokinetic drug interactions with Fasenra. Seek urgent medical attention if you experience shortness of breath, or facial or throat tightness after administering Fasenra. It should be clear and colorless or slightly yellow. Some people may have an allergic reaction to Fasenra. You can also ask your doctor if one of these drugs may be right for you. If youre pregnant and have already taken Fasenra during your pregnancy, you may be able to join the Fasenra & Pregnancy Study. May be used as an add-on maintenance treatment for severe eosinophilic asthma in adults and children aged 12 years old and older. For more information on the effectiveness of Fasenra, see the Fasenra uses section below. A biologic is made from parts of living organisms. Before using, take one Fasenra autoinjector out of the refrigerator, and leave it to warm up to room temperature for 30 to 40 minutes. To learn about other mild side effects, talk with your doctor or pharmacist, or read Fasenras prescribing information. This enhances apoptosis, or programmed cell death, of eosinophils via a process called antibody-dependent cell-mediated cytotoxicity (ADCC). Asthma is a condition in which your airways become swollen, making it hard to breathe.

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